Open AccessTranslocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy
Author(s) -
Fumiko Kodama,
Katsuhiko Asanuma,
Miyuki Takagi,
Teruo Hidaka,
Etsuko Asanuma,
Hiromitsu Fukuda,
Takuto Seki,
Yukihiko Takeda,
Yoshiko Hosoe-Nagai,
Rin Asao,
Satoshi Horikoshi,
Yasuhiko Tomino
Publication year - 2012
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfs500
Subject(s) - podocyte , medicine , slit diaphragm , nephropathy , minimal change disease , podocalyxin , glomerulonephritis , renal biopsy , nephrotic syndrome , pathology , endocrinology , biopsy , kidney , proteinuria , focal segmental glomerulosclerosis , diabetes mellitus
It has been reported that podocytopenia has been occurring with increasing disease severity in patients with IgA nephropathy (IgAN). Dendrin is localized at the slit diaphragm (SD) in podocytes. We showed that dendrin translocates to the nucleus of injured podocytes in experimental nephritis and the nuclear dendrin promotes podocyte apoptosis. It is still unknown whether dendrin translocates from the SD to podocyte nucleus in IgAN. We investigated the presence of nuclear dendrin in patients with IgAN and the association between the translocated dendrin to the podocyte nucleus and disease activity.
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