Secreted Klotho and FGF23 in chronic kidney disease Stage 1 to 5: a sequence suggested from a cross-sectional study
Author(s) -
Ivana Pavik,
Philippe Jaeger,
Lena Ebner,
Carsten A. Wagner,
Katja Petzold,
Daniela Egli-Spichtig,
Diane Poster,
Rudolf P. Wüthrich,
Stefan Russmann,
Andreas L. Serra
Publication year - 2012
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfs460
Subject(s) - klotho , medicine , kidney disease , endocrinology , fibroblast growth factor 23 , renal function , parathyroid hormone , calcitriol , vitamin d and neurology , vitamin d deficiency , calcium , kidney
Klotho and fibroblast growth factor 23 (FGF23) are key regulators of mineral metabolism in renal insufficiency. FGF23 levels have been shown to increase early in chronic kidney disease (CKD); however, the corresponding soluble Klotho levels at the different CKD stages are not known.
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