Peroxisome proliferator-activated receptor- activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in Type 2 diabetes | Zendy

Eun Young Lee | Zendy; G. T. Kim | Zendy; Min Kyung Hyun | Zendy; Sohee Kim | Zendy; Seung Hyeok Seok | Zendy; Rino Choi | Zendy; M. Y. Lee | Zendy; Choon Hee Chung | Zendy

Open Access

Peroxisome proliferator-activated receptor- activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in Type 2 diabetes

Author(s) -

Eun Young Lee,

G. T. Kim,

Min Kyung Hyun,

Sohee Kim,

Seung Hyeok Seok,

Rino Choi,

M. Y. Lee,

Choon Hee Chung

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs358

Subject(s) - medicine , nephrin , peroxisome proliferator activated receptor , albuminuria , diabetic nephropathy , rosiglitazone , podocyte , endocrinology , agonist , transcription factor , receptor , diabetes mellitus , cancer research , kidney , proteinuria , biology , gene , biochemistry

Peroxisome proliferator-activated receptor (PPAR)-δ is a ligand-activated transcription factor in regulating gene expression and is believed to play an important role in various kidney diseases including diabetic nephropathy. This study investigated the efficacy of GW610742, a highly specific agonist for PPAR-δ, for the treatment of diabetic nephropathy.

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