Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury | Zendy

Neng Fisheri Kurniati | Zendy; Matijs van Meurs | Zendy; Franziska vom Hagen | Zendy; Rianne M. Jongman | Zendy; Jill Moser | Zendy; Peter J. Zwiers | Zendy; Michel Struys | Zendy; Johanna Westra | Zendy; Jan G. Zijlstra | Zendy; HansPeter Hammes | Zendy; Grietje Molema | Zendy; Peter Heeringa | Zendy

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Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury

Author(s) -

Neng Fisheri Kurniati,

Matijs van Meurs,

Franziska vom Hagen,

Rianne M. Jongman,

Jill Moser,

Peter J. Zwiers,

Michel Struys,

Johanna Westra,

Jan G. Zijlstra,

HansPeter Hammes,

Grietje Molema,

Peter Heeringa

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs336

Subject(s) - lipopolysaccharide , medicine , acute kidney injury , sepsis , kidney , creatinine , endocrinology , cytokine , renal function , blood urea nitrogen , inflammation , tumor necrosis factor alpha , albumin , immunology

In sepsis and various other inflammatory conditions, elevated circulating levels of angiopoietin-2 (Ang2) are detected, but the precise functional role of Ang2 in these conditions is not well understood. Here, we investigated the contribution of Ang2 to the inflammatory response and renal function impairment in a mouse model of endotoxaemia.

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