Effects of lipid-lowering treatment on platelet reactivity and platelet-leukocyte aggregation in diabetic patients without and with chronic kidney disease: a randomized trial | Zendy

Tora Almquist | Zendy; Stefan H. Jacobson | Zendy; P. E. Lins | Zendy; Richard W. Farndale | Zendy; Paul Hjemdahl | Zendy

Open Access

Effects of lipid-lowering treatment on platelet reactivity and platelet-leukocyte aggregation in diabetic patients without and with chronic kidney disease: a randomized trial

Author(s) -

Tora Almquist,

Stefan H. Jacobson,

P. E. Lins,

Richard W. Farndale,

Paul Hjemdahl

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs183

Subject(s) - medicine , kidney disease , simvastatin , platelet , renal function , diabetes mellitus , endocrinology , gastroenterology , placebo , platelet activation , von willebrand factor , pathology , alternative medicine

Diabetes mellitus (DM) is associated with hyperreactive platelets and increased platelet-leukocyte aggregation (PLA), but the impact of concomitant chronic kidney disease (CKD) has been much less studied. Lipid-lowering treatment (LLT) may have favorable effects on platelet activation and inflammation. The objective of this mechanistic study was to investigate the impact of CKD on platelet function and inflammatory parameters in patients with DM and the effects of LLT.

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