Open AccessCharacterization of vitamin D-deficient klotho-/- mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho-/- mice?
Author(s) -
Titia E. Woudenberg-Vrenken,
Bram C. J. van der Eerden,
Annemiete W.C.M. van der Kemp,
Johannes P.T.M. van Leeuwen,
R. J. M. Bindels,
Joost G.J. Hoenderop
Publication year - 2012
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfs177
Subject(s) - klotho , homeostasis , endocrinology , medicine , vitamin d and neurology , calcium , calcium metabolism , calcitriol , vitamin , vitamin d deficiency , phosphate , calcifediol , kidney , chemistry , biochemistry
Klotho(-/-) mice display disturbed Ca(2+) and vitamin D homeostasis. Renal cytochrome p450 27b1 (Cyp27b1), the enzyme that catalyzes the hydrolysis to 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), is increased in klotho(-/-) mice, and a 1,25(OH)(2)D(3)-deficient diet partially normalized Ca(2+) homeostasis in these klotho(-/-) mice. The aim of the present study was to further delineate the interplay between 1,25(OH)(2)D(3) and klotho and their relative contribution to the Ca(2+) homeostasis of klotho(-/-) mice.
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