Human proximal tubule epithelial cells modulate autologous dendritic cell function | Zendy

Andrew J. Kassianos | Zendy; Sandeep Sampangi | Zendy; Xiangju Wang | Zendy; Kathrein E. Roper | Zendy; Kenneth W. Beagley | Zendy; Helen Healy | Zendy; Ray Wilkinson | Zendy

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Human proximal tubule epithelial cells modulate autologous dendritic cell function

Author(s) -

Andrew J. Kassianos,

Sandeep Sampangi,

Xiangju Wang,

Kathrein E. Roper,

Kenneth W. Beagley,

Helen Healy,

Ray Wilkinson

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs136

Subject(s) - medicine , context (archaeology) , immune system , microbiology and biotechnology , apposition , dendritic cell , kidney , epithelium , immunology , pathology , anatomy , endocrinology , biology , paleontology

We have previously demonstrated that human kidney proximal tubule epithelial cells (PTEC) are able to modulate autologous T and B lymphocyte responses. It is well established that dendritic cells (DC) are responsible for the initiation and direction of adaptive immune responses and that these cells occur in the renal interstitium in close apposition to PTEC under inflammatory disease settings. However, there is no information regarding the interaction of PTEC with DC in an autologous human context.

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