Previous ischemia and reperfusion injury results in resistance of the kidney against subsequent ischemia and reperfusion insult in mice; a role for the Akt signal pathway | Zendy

HeeSeong Jang | Zendy; J. Kim | Zendy; K. Y. Kim | Zendy; Jin Il Kim | Zendy; Min Hyun Cho | Zendy; K. M. Park | Zendy

Open Access

Previous ischemia and reperfusion injury results in resistance of the kidney against subsequent ischemia and reperfusion insult in mice; a role for the Akt signal pathway

Author(s) -

HeeSeong Jang,

J. Kim,

K. Y. Kim,

Jin Il Kim,

Min Hyun Cho,

K. M. Park

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs097

Subject(s) - wortmannin , medicine , protein kinase b , ischemia , kidney , apoptosis , reperfusion injury , endocrinology , pi3k/akt/mtor pathway , creatinine , pharmacology , biology , biochemistry

Kidneys previously exposed to ischemia and reperfusion (I/R), pre-conditioned by I/R, are less susceptible to subsequent I/R injury. Here, we investigated the role for protein kinase B (Akt) survival signaling pathways including anti-apoptosis pathways in the reduced susceptibility of I/R-pre-conditioned kidneys.

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