Opening a treasure chest: glomerular proteome analyses of formalin-fixed paraffin-embedded kidney tissue in the investigation of diabetic nephropathy | Zendy

Andreas Blutke | Zendy

Open Access

Opening a treasure chest: glomerular proteome analyses of formalin-fixed paraffin-embedded kidney tissue in the investigation of diabetic nephropathy

Author(s) -

Andreas Blutke

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs082

Subject(s) - medicine , diabetic nephropathy , kidney , proteome , treasure , pathology , urology , bioinformatics , philosophy , theology , biology

Worldwide, diabetic nephropathy (DN) persists as a major complication of diabetes mellitus (DM), affecting approximately one-third of DM patients [1]. DN is characterized by development of progressive glomerulosclerotic and tubulointerstitial kidney lesions gradually leading to an increasing loss of functioning kidney parenchyma [2]. As therapeutic intervention is frequently insufficient to prevent development of DN and its progression to end-stage renal 1695

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