Saquinavir in steroid-dependent and -resistant nephrotic syndrome: a pilot study | Zendy

Rosanna Coppo | Zendy; Roberta Camilla | Zendy; M. G. Porcellini | Zendy; Licia Peruzzi | Zendy; Bruno Gianoglio | Zendy; Alessandro Amore | Zendy; Valentina Daprà | Zendy; E. Loiacono | Zendy; Valentina Fonsato | Zendy; Antonio Dal Canton | Zendy; Ciro Esposito | Zendy; Pasquale Esposito | Zendy; PierAngelo Tovo | Zendy

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Saquinavir in steroid-dependent and -resistant nephrotic syndrome: a pilot study

Author(s) -

Rosanna Coppo,

Roberta Camilla,

M. G. Porcellini,

Licia Peruzzi,

Bruno Gianoglio,

Alessandro Amore,

Valentina Daprà,

E. Loiacono,

Valentina Fonsato,

Antonio Dal Canton,

Ciro Esposito,

Pasquale Esposito,

PierAngelo Tovo

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs035

Subject(s) - medicine , nephrotic syndrome , prednisone , proteinuria , saquinavir , protease inhibitor (pharmacology) , protease , endocrinology , immunology , gastroenterology , pharmacology , human immunodeficiency virus (hiv) , antiretroviral therapy , kidney , biochemistry , viral load , enzyme , chemistry

Some difficult cases of idiopathic nephrotic syndrome (NS) have been treated with a HIV protease inhibitor provided with proteasome-inhibiting activity. The objective of this study was to limit nuclear factor κB (NF-κB) activation which is up-regulated in these patients, aiming at decreasing proteinuria and prednisone need.

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