Cold ischaemia, innate immunity and deterioration of the glomerular filtration barrier in antibody-mediated acute rejection | Zendy

Èlia Ripoll | Zendy; Víctor Nacher | Zendy; August Vidal | Zendy; E. Marcos Herrero | Zendy; Núria Bolaños | Zendy; Joan Torrás | Zendy; Josep M. Grinyó | Zendy; Jesús Ruberte | Zendy; I. Herrero | Zendy

Open Access

Cold ischaemia, innate immunity and deterioration of the glomerular filtration barrier in antibody-mediated acute rejection

Author(s) -

Èlia Ripoll,

Víctor Nacher,

August Vidal,

E. Marcos Herrero,

Núria Bolaños,

Joan Torrás,

Josep M. Grinyó,

Jesús Ruberte,

I. Herrero

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs003

Subject(s) - medicine , innate immune system , immunology , glomerular basement membrane , transplantation , acquired immune system , immunity , proteinuria , immune system , kidney

In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. Acute rejection episodes are a risk factor for late allograft dysfunction and proteinuria. This implies some alteration of the glomerular filtration barrier (GFB). Besides its effects on acute rejection, we hypothesized that CI might somehow damage the GFB being directly responsible for late proteinuria.

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