Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage | Zendy

Ngwi Fet | Zendy; Anette Fiebeler | Zendy; U. Klinge | Zendy; JeKyun Park | Zendy; Stefan Barth | Zendy; Theo Thepen | Zendy; René H. Tolba | Zendy

Open Access

Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage

Author(s) -

Ngwi Fet,

Anette Fiebeler,

U. Klinge,

JeKyun Park,

Stefan Barth,

Theo Thepen,

René H. Tolba

Publication year - 2012

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr792

Subject(s) - medicine , oxidative stress , ischemia , reperfusion injury , reduction (mathematics) , kidney disease , cardiology , geometry , mathematics

Macrophages are major effectors of the local inflammatory response syndrome (LIRS) and influence the extent of ischaemia/reperfusion injury, thereby impacting organ function. Several subgroups of macrophages exist, representing distinct modes of action. The specific role of the subset expressing Fc gamma receptor (FcγR) 1 in the activated state of macrophages is poorly defined.

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