Open AccessLight-microscopic characteristics of IgG4-related tubulointerstitial nephritis: distinction from non-IgG4-related tubulointerstitial nephritis
Author(s) -
Kazuhiro Yoshita,
Mitsuhiro Kawano,
Ichiro Mizushima,
Satoshi Hara,
Yumi Ito,
Naofumi Imai,
Mitsuhiro Ueno,
Shinichi Nishi,
Hideki Nomura,
Ichiei Narita,
Takako Saeki
Publication year - 2012
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr761
Subject(s) - pathology , medicine , infiltration (hvac) , fibrosis , igg4 related disease , pathological , nephritis , mononuclear cell infiltration , interstitial nephritis , biopsy , kidney , physics , thermodynamics
IgG4-related disease is a multi-organ disorder characterized by a high level of serum IgG4 and dense infiltration of IgG4-positive cells into affected organs. In routine studies, however, IgG subclasses are not estimated. In the present study, we attempted to clarify the light-microscopic characteristics of IgG4-related tubulointerstitial nephritis (TIN) to facilitate distinction from non-IgG4-related TIN in specimens obtained by renal biopsy using routine staining.
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