Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis | Zendy

Shinya Nakatani | Zendy; Min Wei | Zendy; Eiji Ishimura | Zendy; Anna Kakehashi | Zendy; Katsuhito Mori | Zendy; Yoshiki Nishizawà | Zendy; Masaaki Inaba | Zendy; Hideki Wanibuchi | Zendy

Open Access

Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis

Author(s) -

Shinya Nakatani,

Min Wei,

Eiji Ishimura,

Anna Kakehashi,

Katsuhito Mori,

Yoshiki Nishizawà,

Masaaki Inaba,

Hideki Wanibuchi

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr682

Subject(s) - diabetic nephropathy , medicine , glomerulosclerosis , diabetes mellitus , pathology , kidney , nephropathy , proteome , renal biopsy , urology , renal function , renal pathology , kidney disease , immunohistochemistry , proteinuria , endocrinology , biology , bioinformatics

To date, little proteomic information has been available from the glomeruli of diabetic patients, possibly due to the clinical limitations of renal biopsy in diabetic patients and insufficient quantities of such specimens for proteome analysis. The purpose of the present study was to identify altered protein expression profiles in diabetic glomeruli using formalin-fixed paraffin-embedded (FFPE) kidney tissues from diabetic patients.

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