eNOS gene delivery prevents hypertension and reduces renal failure and injury in rats with reduced renal mass | Zendy

S. Savard | Zendy; Pascal M. Lavoie | Zendy; Catherine Villeneuve | Zendy; Mohsen Agharazii | Zendy; Michel Lebel | Zendy; Roxanne Larivière | Zendy

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eNOS gene delivery prevents hypertension and reduces renal failure and injury in rats with reduced renal mass

Author(s) -

S. Savard,

Pascal M. Lavoie,

Catherine Villeneuve,

Mohsen Agharazii,

Michel Lebel,

Roxanne Larivière

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr641

Subject(s) - medicine , endocrinology , creatinine , enos , glomerulosclerosis , proteinuria , blood pressure , renal function , kidney , renal cortex , urology , nitric oxide synthase , nitric oxide

Impaired nitric oxide (NO) release in chronic renal failure has been implicated in the pathogenesis of hypertension and the progression of renal insufficiency. We investigated whether gene delivery of the endothelial NO synthase (eNOS) improves NO release and reduces blood pressure and renal failure and injury in rats with reduced renal mass.

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