High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α pathway | Zendy

Hyun Wha Chung | Zendy; Ji Hee Lim | Zendy; Min Young Kim | Zendy; Seok Joon Shin | Zendy; Sungjin Chung | Zendy; Bum Soon Choi | Zendy; Hyung Wook Kim | Zendy; YongSoo Kim | Zendy; Cheol Whee Park | Zendy; Yoon Sik Chang | Zendy

Open Access

High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α pathway

Author(s) -

Hyun Wha Chung,

Ji Hee Lim,

Min Young Kim,

Seok Joon Shin,

Sungjin Chung,

Bum Soon Choi,

Hyung Wook Kim,

YongSoo Kim,

Cheol Whee Park,

Yoon Sik Chang

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr613

Subject(s) - endocrinology , medicine , fenofibrate , oxidative stress , peroxisome proliferator activated receptor , lipotoxicity , insulin resistance , receptor , insulin

The peroxisome proliferator-activated receptor-α (PPARα) is a lipid-sensing transcriptional factor that has a role in gluco-oxidative stress and lipotoxicity. Forkhead box O (FoxO)s and peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α are also known to regulate cell metabolism, cell cycle arrest, apoptosis and oxidative stress during stressful conditions. We evaluated whether PPARα-FoxOs-PGC-1α signaling in overfed spontaneously hypertensive rats (SHR) has a protective role in the kidney.

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