High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage | Zendy

Stella Bernardi | Zendy; Barbara Toffoli | Zendy; Cristina Zennaro | Zendy; Christos Tikellis | Zendy; Silvia Monticone | Zendy; Pasquale Losurdo | Zendy; Giuseppe Bellini | Zendy; Merlin C. Thomas | Zendy; Francesco Fallo | Zendy; Franco Veglio | Zendy; Colin I. Johnston | Zendy; Bruno Fabris | Zendy

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High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage

Author(s) -

Stella Bernardi,

Barbara Toffoli,

Cristina Zennaro,

Christos Tikellis,

Silvia Monticone,

Pasquale Losurdo,

Giuseppe Bellini,

Merlin C. Thomas,

Francesco Fallo,

Franco Veglio,

Colin I. Johnston,

Bruno Fabris

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr600

Subject(s) - medicine , oxidative stress , kidney , endocrinology , renin–angiotensin system , angiotensin ii , oxidative damage , enzyme , angiotensin converting enzyme 2 , angiotensin converting enzyme , biochemistry , biology , blood pressure , covid-19 , disease , infectious disease (medical specialty)

Angiotensin II (AngII) contributes to salt-driven kidney damage. In this study, we aimed at investigating whether and how the renal damage associated with a high-salt diet could result from changes in the ratio between angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2).

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