Open AccessUrinary organic anion transporter protein profiles in AKI
Author(s) -
Margarita Kunin,
Eliezer J. Holtzman,
Semyon Melnikov,
Dganit Dinour
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr541
Subject(s) - acute kidney injury , medicine , organic anion transporter 1 , urinary system , kidney , urine , urology , creatinine , excretion , urine osmolality , apical membrane , epithelial polarity , endocrinology , pathology , transporter , biochemistry , chemistry , epithelium , gene
Organic anion transporters (OATs) are located on either the basolateral or the apical membrane of the proximal tubule cell and mediate the absorption and secretion of various drugs and endogenous metabolites. It has been shown that cellular damage in acute kidney injury (AKI) involves three forms of injury: sublethal damage resulting in loss of cell polarity, cell death through apoptosis and necrosis. We hypothesize that cellular mistargeting of OAT proteins in AKI will change the profile of OAT proteins in urine.
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