Open AccessInterpretation of serum PTH concentrations with different kits in dialysis patients according to the KDIGO guidelines: importance of the reference (normal) values
Author(s) -
Étienne Cavalier,
Pierre Delanaye,
L. Vranken,
Anne-Catherine Bekaert,
Agnès Carlisi,
J.-P. Chapelle,
Jean–Claude Souberbielle
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr535
Subject(s) - medicine , reference values , reference range , parathyroid hormone , vitamin d and neurology , population , dialysis , inclusion and exclusion criteria , renal function , urology , hemodialysis , endocrinology , pathology , environmental health , alternative medicine , calcium
The recommended target range for serum parathyroid hormone (PTH) in dialysis patients has changed from 150 to 300 pg/mL in the KDOQI guidelines to two to nine times the upper normal limit in the KDIGO ones. Although inclusion/exclusion criteria for the reference population are highly important, they are usually not mentioned in the commercial kits. In this study, we used the same reference population of vitamin D-replete normal subjects to establish reference values for 10 commercial PTH kits. We evaluated whether this may improve the classification of dialysis patients according to the KDIGO compared to the use of reference values proposed by the manufacturers.
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