Open AccessAbsence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy
Author(s) -
Zhiyong Qu,
Gang Liu,
Jian Ping Li,
Lei Wu,
Ying Tan,
Xin Zheng,
Junhong Ao,
MingHui Zhao
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr534
Subject(s) - medicine , membranous nephropathy , pathological , malignancy , hypoalbuminemia , pathogenesis , gastroenterology , nephropathy , pathology , hazard ratio , proteinuria , confidence interval , endocrinology , kidney , diabetes mellitus
The renal pathological manifestations of malignancy-associated membranous nephropathy (M-MN) and idiopathic membranous nephropathy (I-MN) are similar. It has been suggested that glomerular IgG4 deposition may play an important role in the pathogenesis of I-MN. In the present study, we compared the IgG subclass of immune complex deposition, clinical data and pathological data of patients with M-MN and I-MN.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom