Open AccessEfficacy and safety of regional citrate anticoagulation in liver transplant patients requiring post-operative renal replacement therapy
Author(s) -
Fuat H. Saner,
Juergen Treckmann,
Alexander Geis,
Christian Lösch,
Oliver Witzke,
Ali Canbay,
Stephan Herget-Rosenthal,
Andreas Kribben,
Andreas Paul,
Thorsten Feldkamp
Publication year - 2011
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr510
Subject(s) - medicine , renal replacement therapy , renal transplant , surgery , hemodialysis , liver transplantation , intensive care medicine , urology , transplantation
Liver transplant patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) early post-operatively are at high risk for bleeding. Using heparin for anticoagulation during CRRT may contribute to the increased bleeding risk. Regional anticoagulation with citrate may decrease the risk of bleeding. However, citrate anticoagulation may be associated with metabolic complications in patients with liver impairment. The aim of the study was to evaluate the safety and efficacy of citrate anticoagulation in liver transplant patients.