The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population | Zendy

Jaroslav A. Hubáček | Zendy; Ondřej Viklický | Zendy; Dana Dlouhá | Zendy; Silvie Rajnochová­ Bloudíčková | Zendy; Růžena Kubínová | Zendy; Anne Peasey | Zendy; Hynek Pikhart | Zendy; Věra Adámkova | Zendy; Irena Brabcová | Zendy; Eva Pokorná | Zendy; Martin Bobák | Zendy

Open Access

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population

Author(s) -

Jaroslav A. Hubáček,

Ondřej Viklický,

Dana Dlouhá,

Silvie Rajnochová Bloudíčková,

Růžena Kubínová,

Anne Peasey,

Hynek Pikhart,

Věra Adámkova,

Irena Brabcová,

Eva Pokorná,

Martin Bobák

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr418

Subject(s) - medicine , end stage renal disease , odds ratio , kidney disease , fto gene , population , genotype , transplantation , single nucleotide polymorphism , confidence interval , gastroenterology , case control study , hemodialysis , gene , genetics , biology , environmental health

Genome-wide association studies identified the FTO (fat mass and obesity gene) gene as an important determinant of body weight. More recently, the FTO gene was reported to be associated with other outcomes, including major risk factors for chronic kidney disease (CKD). We investigated the role of this gene in the risk of end-stage renal disease (ESRD) caused by CKD.

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