Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient | Zendy

Isioma Onyekpe | Zendy; Mohan Shenoy | Zendy; Helen Denley | Zendy; Hany Riad | Zendy; Nicholas J.A. Webb | Zendy

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Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient

Author(s) -

Isioma Onyekpe,

Mohan Shenoy,

Helen Denley,

Hany Riad,

Nicholas J.A. Webb

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr352

Subject(s) - medicine , tacrolimus , prednisolone , transplantation , immunosuppression , interstitial nephritis , renal function , renal biopsy , uveitis , nephritis , kidney transplantation , biopsy , gastroenterology , immunology , kidney

We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation. Our patient was diagnosed at the age of 8 years and, despite treatment with systemic steroids, developed established renal failure. At the age of 17 years, he underwent a live-related donor renal transplant. Immunosuppression included tacrolimus, mycophenolate mofetil and prednisolone. Having had normal renal function for 3 years after transplantation, he developed uveitis and decline in the graft function. A biopsy of the allograft demonstrated recurrent granulomatous interstitial nephritis. The recurrence of TINU following transplantation suggests a role for circulating autoantibodies in the disease pathology.

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