Matrix-embedded endothelial cells are protected from the uremic milieu | Zendy

Vipul C. Chitalia | Zendy; Sylaja Murikipudi | Zendy; Laura Indolfi | Zendy; Leina Al Rabadi | Zendy; R. Valdez | Zendy; Joseph W. Franses | Zendy; Elazer R. Edelman | Zendy

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Matrix-embedded endothelial cells are protected from the uremic milieu

Author(s) -

Vipul C. Chitalia,

Sylaja Murikipudi,

Laura Indolfi,

Leina Al Rabadi,

R. Valdez,

Joseph W. Franses,

Elazer R. Edelman

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr337

Subject(s) - uremia , viability assay , trypan blue , medicine , apoptosis , cell growth , vascular smooth muscle , cyclin d1 , andrology , extracellular matrix , cell cycle , microbiology and biotechnology , endocrinology , biology , biochemistry , cancer , smooth muscle

Endothelial cells (ECs) embedded in 3D matrices [matrix-embedded endothelial cells (MEECs)] of denatured collagen implanted around vascular access anastomoses preserve luminal patency. MEEC implant efficacy depends on embedded EC health. As the uremic milieu inhibits proliferation and induces apoptosis of ECs, we examined whether uremia might impact MEECs.

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