Apoptosis occurs differentially according to glomerular size in diabetic kidney disease | Zendy

Dong-Il Jung | Zendy; Sang Hoon Lee | Zendy; S.-J. Kwak | Zendy; J. J. Li | Zendy; DoHyeong Kim | Zendy; B. Y. Nam | Zendy; Hye Young Kang | Zendy; Tara I. Chang | Zendy; Jung Tak Park | Zendy; Seung Hyeok Han | Zendy; TaeHyun Yoo | Zendy; ShinWook Kang | Zendy

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Apoptosis occurs differentially according to glomerular size in diabetic kidney disease

Author(s) -

Dong-Il Jung,

Sang Hoon Lee,

S.-J. Kwak,

J. J. Li,

DoHyeong Kim,

B. Y. Nam,

Hye Young Kang,

Tara I. Chang,

Jung Tak Park,

Seung Hyeok Han,

TaeHyun Yoo,

ShinWook Kang

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr301

Subject(s) - protein kinase b , medicine , diabetic nephropathy , apoptosis , podocyte , diabetes mellitus , nephropathy , kidney disease , kidney , endocrinology , cancer research , proteinuria , biology , biochemistry

Apoptosis, which is involved in the process of mesangial cell and podocyte loss in diabetic nephropathy, is known to be regulated by protein kinase B/Akt (Akt). A number of studies have therefore investigated the activity of Akt under diabetic conditions, but the results have not been consistent. In this study, we hypothesized that apoptosis may occur differentially and that Akt may be differentially activated according to glomerular size in diabetic kidney disease.

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