Open AccessLeft ventricular periostin gene expression is associated with fibrogenesis in experimental renal insufficiency
Author(s) -
Virva Pohjolainen,
Jaana Rysä,
Juha Näpänkangas,
Peeter Kööbi,
Arttu Eräranta,
Mika Ilves,
Raisa Serpi,
Ilkka Pörsti,
Heikki Ruskoaho
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr279
Subject(s) - periostin , medicine , matricellular protein , left ventricular hypertrophy , fibrosis , calcification , pathological , kidney disease , cardiology , kidney , renal function , muscle hypertrophy , pathology , extracellular matrix , blood pressure , microbiology and biotechnology , biology
Cardiovascular diseases are the most important cause of death in patients with impaired kidney function. Left ventricular hypertrophy (LVH), cardiac interstitial fibrosis and cardiovascular calcifications are characteristic of chronic renal insufficiency (CRI). Periostin is a fibrogenesis- and calcification-related matricellular protein re-expressed in adult tissues undergoing remodelling in response to pathological stimuli. The role of periostin in CRI-induced LVH is unknown.
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