Open AccessVasopressin secretion by hypertonic saline infusion during hemodialysis: effect of cardiopulmonary recirculation
Author(s) -
Kenji Shimizu,
Toshiki Kurosawa,
R. Ishikawa,
T Sanjo
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr272
Subject(s) - medicine , hypertonic saline , vasopressin , osmole , saline , mean arterial pressure , anesthesia , plasma osmolality , hemodialysis , blood pressure , tonicity , endocrinology , heart rate
Intradialytic hypotension is the most common and severe acute complication of hemodialysis therapy. In our previous study, infusion of 20 mL of 10% saline into the venous line of a dialyzer increased blood pressure during dialysis hypotension by stimulating arginine vasopressin (AVP) secretion, independent of its effect on plasma volume (PV). This study examines the mechanism by which a small amount of hypertonic solution stimulates AVP secretion.
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