Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis | Zendy

Bülent Tokgöz | Zendy; Cahit Uçar | Zendy; İsmail Koçyiğit | Zendy; Mehmet Akif Somdaş | Zendy; Ali Ekrem Ünal | Zendy; Alperen Vural | Zendy; Murat Hayri Sipahioğlu | Zendy; Oktay Oymak | Zendy; Cengiz Utaş | Zendy

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Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis

Author(s) -

Bülent Tokgöz,

Cahit Uçar,

İsmail Koçyiğit,

Mehmet Akif Somdaş,

Ali Ekrem Ünal,

Alperen Vural,

Murat Hayri Sipahioğlu,

Oktay Oymak,

Cengiz Utaş

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr211

Subject(s) - medicine , ototoxicity , continuous ambulatory peritoneal dialysis , peritonitis , peritoneal dialysis , acetylcysteine , amikacin , vancomycin , anesthesia , surgery , antibiotics , chemotherapy , staphylococcus aureus , biochemistry , chemistry , genetics , microbiology and biotechnology , bacteria , cisplatin , biology , antioxidant

Peritonitis is currently one of the leading complications of continuous ambulatory peritoneal dialysis (CAPD) treatment. Aminoglycosides and vancomycin are used in the treatment of CAPD peritonitis despite their potential risk for ototoxicity. N-acetylcysteine (NAC) is a molecule used in the treatment and prophylaxis of many diseases related to oxidative stress. The aim of this study was to examine whether ototoxicity due to antibiotics used in the treatment of CAPD peritonitis can be prevented by NAC.

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