Open AccessPPAR 2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case-control studies
Author(s) -
Salvatore De Cosmo,
Sabrina Prudente,
Olga Lamacchia,
Emanuela Lapice,
Eleonora Morini,
Rosa Di Paola,
Massimiliano Copetti,
Piero Ruggenenti,
Giuseppe Remuzzi,
Olga Vaccaro,
Mauro Cignarelli,
Vincenzo Trischitta
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr187
Subject(s) - albuminuria , medicine , odds ratio , diabetic nephropathy , confidence interval , type 2 diabetes , diabetes mellitus , meta analysis , insulin resistance , nephropathy , microalbuminuria , case control study , gastroenterology , endocrinology
Insulin resistance has a role in diabetic nephropathy. The A12 variant of the PPARγ2 P121A polymorphism has been firmly associated with reduced risk of insulin resistance, while its role on the risk of albuminuria in patients with type 2 diabetes is uncertain. This study investigated whether the PPARγ2 P12A polymorphism modulates the risk of albuminuria in these patients.
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