Open AccessCapillary rarefaction in advanced chronic kidney disease is associated with high phosphorus and bicarbonate levels
Author(s) -
Oanh H.D. Thang,
Erik H. Serné,
Muriel P.C. Grooteman,
Yvo M. Smulders,
Piet M. ter Wee,
Geert Jan Tangelder,
Menso J. Nubé
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr089
Subject(s) - medicine , kidney disease , perfusion , kidney , endocrinology , cardiology
In patients with chronic kidney disease (CKD), disorders of mineral metabolism are associated with vascular calcifications and mortality. Microvascular dysfunction, by affecting flow resistance and tissue perfusion, may explain the cardiovascular sequelae of CKD-associated disorders of mineral metabolism. We investigated whether advanced CKD is associated with a decrease in the functional and structural number of capillaries in skin and subsequently whether capillary rarefaction is related to mineral metabolism.
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