Open AccessTGF-beta1 reduces Wilms' tumor suppressor gene expression in podocytes
Author(s) -
Toru Sakairi,
Yoshifusa Abe,
Jeffrey B. Kopp
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfr061
Subject(s) - podocyte , gene knockdown , glomerulosclerosis , transforming growth factor , biology , cancer research , small hairpin rna , messenger rna , microbiology and biotechnology , wilms' tumor , transgene , enhancer , transforming growth factor beta , gene expression , endocrinology , medicine , kidney , cell culture , gene , proteinuria , biochemistry , genetics
Wilms' tumor suppressor gene (WT1) is essential for normal podocyte function, and transforming growth factor (TGF)-beta contributes to focal segmental glomerulosclerosis (FSGS). We aimed to address whether TGF-beta affects WT1 expression in podocytes.
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