Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats | Zendy

Jianping Zuo | Zendy; Aslam Khan | Zendy; Patricia A. Glenton | Zendy; Saeed R. Khan | Zendy

Open Access

Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats

Author(s) -

Jianping Zuo,

Aslam Khan,

Patricia A. Glenton,

Saeed R. Khan

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr035

Subject(s) - apocynin , endocrinology , medicine , kidney , nadph oxidase , calcium oxalate , excretion , osteopontin , nicotinamide adenine dinucleotide phosphate , oxalate , urinary system , oxidase test , chemistry , biochemistry , oxidative stress , enzyme , organic chemistry

Renal calcium oxalate (CaOx) crystal deposition is associated with epithelial injury and movement of inflammatory cells into the interstitium. We have proposed that oxalate (Ox)- and CaOx crystal-induced injury is most likely caused by reactive oxygen species (ROS) produced by activation of membrane nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.

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