Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea | Zendy

Jong Cheol Jeong | Zendy; YoungHwan Hwang | Zendy; Hyosang Kim | Zendy; Han Ro | Zendy; Hayne Cho Park | Zendy; Yoon Jung Kim | Zendy; Myung-Gyu Kim | Zendy; Jongwon Ha | Zendy; Myoung Hee Park | Zendy; DongWan Chae | Zendy; Curie Ahn | Zendy; Jaeseok Yang | Zendy

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Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea

Author(s) -

Jong Cheol Jeong,

YoungHwan Hwang,

Hyosang Kim,

Han Ro,

Hayne Cho Park,

Yoon Jung Kim,

Myung-Gyu Kim,

Jongwon Ha,

Myoung Hee Park,

DongWan Chae,

Curie Ahn,

Jaeseok Yang

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr025

Subject(s) - single nucleotide polymorphism , medicine , haplotype , linkage disequilibrium , transplantation , complement receptor 1 , immunology , snp , kidney transplantation , gastroenterology , complement system , genotype , genetics , immune system , biology , gene

Complements play important roles in both rejection and ischemia-reperfusion injury after transplantation. Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of various immune cells. We investigated the impacts of genetic variations in C5 and its receptor (C5aR) of both recipients and donors on renal allograft outcomes.

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