Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis | Zendy

S. Harding | Zendy; François Provôt | Zendy; JeanBaptiste Beuscart | Zendy; Mark Cook | Zendy; A.R. Bradwell | Zendy; Stephanie Stringer | Zendy; Donald White | Zendy; Paul Cockwell | Zendy; Colin A. Hutchison | Zendy

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Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis

Author(s) -

S. Harding,

François Provôt,

JeanBaptiste Beuscart,

Mark Cook,

A.R. Bradwell,

Stephanie Stringer,

Donald White,

Paul Cockwell,

Colin A. Hutchison

Publication year - 2011

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfr019

Subject(s) - medicine , hemodialysis , multiple myeloma , immunoglobulin light chain , adjuvant , surgery , urology , immunology , antibody

Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.

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