Open AccessAlternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis
Author(s) -
Teresa Bellón,
Virginia Martínez,
Baltasar LucendoVillarin,
Gloria del Peso,
María José Castro,
Luiz Stark Aroeira,
Aránzazu Rodríguez-Sanz,
Marta Ossorio,
Rafael Sánchez,
Rafael Selgas,
M. Auxiliadora Bajo
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq771
Subject(s) - medicine , peritoneal dialysis , peritoneum , cd163 , fibrosis , proinflammatory cytokine , chemokine , peritonitis , immunology , macrophage , population , cytokine , inflammation , pathology , in vitro , biology , biochemistry , environmental health
Depending on the cytokine microenvironment, macrophages (Mϕ) can adopt a proinflammatory (M1) or a profibrotic (M2) phenotype characterized by the expression of cell surface proteins such as CD206 and CD163 and soluble factors such as CC chemokine ligand 18 (CCL18). A key role for Mϕ in fibrosis has been observed in diverse organ settings. We studied the Mϕ population in a human model of peritoneal dialysis in which continuous stress due to dialysis fluids and recurrent peritonitis represent a risk for peritoneal membrane dysfunction reflected as ultrafiltration failure (UFF) and peritoneal fibrosis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom