Open AccessAPOL1 variants and kidney disease. There is no such thing as a free lunch
Author(s) -
Florian Kronenberg
Publication year - 2011
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq753
Subject(s) - kidney disease , medicine , disease , vulnerability (computing) , kidney , genetics , biology , computer security , computer science
A recent study by Genovese et al. unraveled the findings of the intensively discussed gene region around MYH9 and its association with non-diabetic chronic kidney disease in African-Americans. First, it is not the genetic variation in MYH9 but in the neighbouring APOL1 that causes the strong association with disease in African-Americans and second, the study showed strong evidence for a positive selection against vulnerability for Trypanosoma brucei rhodesiense infection but at the price of a higher susceptibility of non-diabetic chronic kidney disease. This overview reviews the findings and the possible impact of the study mentioned above as well as of related studies.
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