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Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic renal disorder with an incidence of 1:1000. Mutations in two genes (PKD1 and PKD2) have been identified as causative. Eighty-five percent of patients with ADPKD carry their mutation in the PKD1 gene. So far, &gt; 500 mutations for PKD1 and &gt; 120 mutations for PKD2, respectively, are known.

Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD)