The MDRD formula does not reflect GFR in ESRD patients | Zendy

Diana C. Grootendorst | Zendy; Wieneke M. Michels | Zendy; J. David Richardson | Zendy; Kitty J. Jager | Zendy; E. W. Boeschoten | Zendy; Friedo W. Dekker | Zendy; Raymond T. Krediet | Zendy

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The MDRD formula does not reflect GFR in ESRD patients

Author(s) -

Diana C. Grootendorst,

Wieneke M. Michels,

J. David Richardson,

Kitty J. Jager,

E. W. Boeschoten,

Friedo W. Dekker,

Raymond T. Krediet

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq667

Subject(s) - medicine , renal function , creatinine , urology , muscle mass , dialysis , kidney disease , endocrinology

The Modification of Diet in Renal Disease (MDRD) equation is widely used for the estimation of glomerular filtration rate (GFR) from plasma creatinine. It has been well validated in patients with various degrees of impaired kidney function, but not in patients with end-stage renal disease (ESRD). Plasma creatinine is determined by GFR and muscle mass. Importance of the latter may increase at low GFR. Our aim was to firstly compare estimated GFR (eGFR by MDRD equation) with measured GFR (mGFR, mean of creatinine and urea clearance) just before the start of dialysis. Secondly, the relationship of eGFR and mGFR with mortality and muscle mass was analysed.

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