Conventional, but not high-purity, dialysate-induced monocyte apoptosis is mediated by activation of PKC- and inflammatory factors release | Zendy

Li Guo | Zendy; Yu Pan | Zendy; Xiaojuan Zhu | Zendy; Lin-ying Tan | Zendy; Qiang Xu | Zendy; Huimin Jin | Zendy

Open Access

Conventional, but not high-purity, dialysate-induced monocyte apoptosis is mediated by activation of PKC- and inflammatory factors release

Author(s) -

Li Guo,

Yu Pan,

Xiaojuan Zhu,

Lin-ying Tan,

Qiang Xu,

Huimin Jin

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq620

Subject(s) - protein kinase c , u937 cell , apoptosis , flow cytometry , microbiology and biotechnology , rottlerin , monocyte , western blot , medicine , kinase , biochemistry , biology , immunology , gene

Use of conventional dialysate (CD) (powdered sodium bicarbonate dissolved manually with reverse osmosis water before dialysis) is common in Chinese haemodialysis (HD) centres. However, this preparation carries the risk of degradation and contamination, potentially negatively impacting host defense. Commercially available high-purity dialysate (HPD) may decrease inflammation and improve nutritional status in HD patients. However, whether HPD affects immune cells is unclear. The purpose of this study was to investigate the in vitro effect of these dialysates on apoptosis in U937 monocytes and its possible mechanism.

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