The angiotensin II receptor type 2 polymorphism influences haemodynamic function and circulating RAS mediators in normotensive humans | Zendy

David Z.I. Cherney | Zendy; Vesta Lai | Zendy; Jonathan Miller | Zendy; J. W. Scholey | Zendy; Heather N. Reich | Zendy

Open Access

The angiotensin II receptor type 2 polymorphism influences haemodynamic function and circulating RAS mediators in normotensive humans

Author(s) -

David Z.I. Cherney,

Vesta Lai,

Jonathan Miller,

J. W. Scholey,

Heather N. Reich

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq564

Subject(s) - medicine , hemodynamics , endocrinology , renin–angiotensin system , receptor , angiotensin ii , polymorphism (computer science) , blood pressure , genetics , genotype , gene , biology

The haemodynamic responses to angiotensin II type 1 (AT1) receptor blockade may be mediated in part by interactions between angiotensin II and the angiotensin II type 2 receptor (AT2R). An AT2R G1675A gene polymorphism has been described, but the functional effects of this polymorphism are unknown.

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