Anti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis | Zendy

Carl F. Bigler | Zendy; Helmut Hopfer | Zendy; Dean J. Danner | Zendy; Monica Schaller | Zendy; Michael J. Mihatsch | Zendy; Marten Trendelenburg | Zendy

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Anti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis

Author(s) -

Carl F. Bigler,

Helmut Hopfer,

Dean J. Danner,

Monica Schaller,

Michael J. Mihatsch,

Marten Trendelenburg

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq558

Subject(s) - lupus nephritis , medicine , nephritis , autoantibody , systemic lupus erythematosus , immunology , glomerulonephritis , antibody , kidney , pathology , disease

In systemic lupus erythematosus patients, a strong association between the occurrence of antibodies against complement C1q (anti-C1q) and lupus nephritis can be observed. However, the predictive value of anti-C1q titres for a renal flare remains to be determined. Increasing titres of anti-C1q before the occurrence of clinical apparent nephritis might not only serve as a clinical parameter but also indicate a direct pathogenic mechanism of anti-C1q.

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