Open AccessC4d staining in post-reperfusion renal biopsy is not useful for the early detection of antibody-mediated rejection when CDC crossmatching is negative
Author(s) -
Elias DavidNeto,
Daísa Silva Ribeiro David,
G. F. Ginani,
H. Rodrigues,
Paulo Sérgio Lopes de Souza,
Maria Cristina Ribeiro de Castro,
Hideki Kanashiro,
Fernando Saito,
R. Falci,
Ioannis Antonopoulos,
Affonso C. Piovesan,
W. C. Nahas
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq549
Subject(s) - medicine , biopsy , antibody , staining , renal biopsy , pathology , kidney , urology , immunology
Sensitized patients (pts) may develop acute antibody-mediated rejection (AMR) due to preformed donor-specific antibodies, undetected by pre-transplant complement-dependent cytotoxicity (CDC) crossmatch (XM). We hypothesized that C4d staining in 1-h post-reperfusion biopsies (1-h Bx) could detect early complement activation in the renal allograft due to preformed donor-specific antibodies.
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