Open AccessAngiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
Author(s) -
H E. Yoon,
Jung Yeon Ghee,
Songlin Piao,
Joon Ho Song,
Dong Han,
S. Kim,
Naro Ohashi,
Hiroyuki Kobori,
Makoto Kuroo,
Chul Woo Yang
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq537
Subject(s) - klotho , endocrinology , losartan , medicine , oxidative stress , kidney , renin–angiotensin system , angiotensin ii , nephropathy , angiotensin ii receptor type 1 , receptor , blood pressure , diabetes mellitus
The Klotho gene plays a role in suppressing ageing-related disorders. It is suggested that activation of renin-angiotensin system (RAS) or oxidative stress suppresses Klotho in the kidney. This study evaluated the association between Klotho expression and RAS in cyclosporine (CsA)-induced renal injury.
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