Open AccessInhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage
Author(s) -
Heloı́sa Della Coletta Francescato,
Fernando Cunha,
R. S. Costa,
Fernando Barbosa Júnior,
Mirian Aparecida Boim,
Carine Prisco Ari,
Cleonice Giovanini Alves da Silva,
Terezila Machado Coimbra
Publication year - 2010
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq447
Subject(s) - medicine , cisplatin , pharmacology , urology , chemotherapy
Cisplatin (CP)-induced renal damage is associated with inflammation. Hydrogen sulphide (H2S) is involved in models of inflammation. This study evaluates the effect of DL-propargylglycine (PAG), an inhibitor of endogenous H2S formation, on the renal damage induced by CP.