Open AccessDisappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy
Author(s) -
Yuko Shima,
Koichi Nakanishi,
Koichi Kamei,
M. Togawa,
Kandai Nozu,
Ryojiro Tanaka,
Satoshi Sasaki,
Kazumoto Iijima,
N. Yoshikawa
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq387
Subject(s) - medicine , prednisolone , proteinuria , mizoribine , mesangial proliferative glomerulonephritis , gastroenterology , nephropathy , azotemia , renal biopsy , renal function , urology , endocrinology , kidney , diabetes mellitus
The prognosis of children with severe IgA nephropathy showing diffuse mesangial proliferation is poor. However, the prognosis can be improved by combination therapy (prednisolone + azathioprine or mizoribine + warfarin + dipyridamole) or prednisolone alone over a 2-year period, and disappearance of glomerular IgA deposits is often observed. Details of the incidence and clinicopathological significance of glomerular IgA disappearance remain unclear.
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