Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis | Zendy

Daniela Bohr | Zendy; Marcus A. Koch | Zendy; M. Kritzenberger | Zendy; Rudolf Fuchshofer | Zendy; Ernst R. Tamm | Zendy

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Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis

Author(s) -

Daniela Bohr,

Marcus A. Koch,

M. Kritzenberger,

Rudolf Fuchshofer,

Ernst R. Tamm

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq366

Subject(s) - myocilin , podocyte , nephrosis , immunohistochemistry , medicine , endocrinology , puromycin , western blot , synaptopodin , podocin , gelsolin , messenger rna , villin , microbiology and biotechnology , kidney , biology , actin , proteinuria , biochemistry , protein biosynthesis , gene , trabecular meshwork , neuroscience , glaucoma

The olfactomedin domain proteins Olfm-1 and myocilin are expressed in podocytes. Myocilin stimulates the formation of focal contacts and actin stress fibres in podocytes and other cell types, effects that are mediated through the Wnt signalling pathway. Here, we tested if the expression of both proteins is modified during puromycin aminonucleoside (PAN) nephrosis, which leads to structural changes in the actin cytoskeleton of podocytes.

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