Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy | Zendy

Sih Min Tan | Zendy; Y. Zhang | Zendy; Alvin J. Cox | Zendy; Darren J. Kelly | Zendy; Weiwei Qi | Zendy

Open Access

Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy

Author(s) -

Sih Min Tan,

Y. Zhang,

Alvin J. Cox,

Darren J. Kelly,

Weiwei Qi

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq355

Subject(s) - medicine , txnip , diabetic nephropathy , oxidative stress , tranilast , endocrinology , fibrosis , diabetes mellitus , sod2 , nephropathy , kidney , pharmacology , superoxide dismutase , thioredoxin

Diabetic nephropathy is the leading cause of kidney failure in the developed world. Tranilast has been reported to not only act as an anti-inflammatory and anti-fibrotic compound, but it also exerts anti-oxidative stress effects in diabetic nephropathy. Thioredoxin-interacting protein (Txnip) is the endogenous inhibitor of the anti-oxidant thioredoxin and is highly up-regulated in diabetic nephropathy, leading to oxidative stress and fibrosis. In this study, we aimed to investigate whether tranilast exerts its anti-oxidant properties through the inhibition of Txnip.

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