Open AccessAntibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy
Author(s) -
Roland Schmitt,
Gunnar Lindahl,
Diana Karpman
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq346
Subject(s) - nephropathy , glomerulonephritis , immunology , medicine , antibody , immunoglobulin a , immunopathology , immunoglobulin g , kidney , endocrinology , diabetes mellitus
IgA nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by mesangial deposits containing predominantly IgA. IgAN commonly occurs or exacerbates after upper respiratory tract infections such as streptococcal pharyngitis. Certain group A streptococci express M proteins with IgA-binding regions (IgA-BRs). We have previously shown that these IgA-BRs co-localize with mesangial IgA in IgAN.
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