Renoprotective potency of amifostine in rat renal ischaemia-reperfusion | Zendy

Michelle Chok | Zendy; Marc Conti | Zendy; Abdelhamid Almolki | Zendy; Sophie Ferlicot | Zendy; Sylvain Loric | Zendy; Antoine Dürrbach | Zendy; G Benoît | Zendy; S. Droupy | Zendy; Pascal Eschwège | Zendy

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Renoprotective potency of amifostine in rat renal ischaemia-reperfusion

Author(s) -

Michelle Chok,

Marc Conti,

Abdelhamid Almolki,

Sophie Ferlicot,

Sylvain Loric,

Antoine Dürrbach,

G Benoît,

S. Droupy,

Pascal Eschwège

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq314

Subject(s) - medicine , amifostine , creatinine , ischemia , endocrinology , lipid peroxidation , reperfusion injury , pharmacology , oxidative stress , chemotherapy

Kidneys from haemodynamically unstable donors may suffer from renal ischaemia-reperfusion (RIR) injury. RIR is associated with reactive oxygen species production that induces inflammation and activates the arachidonic acid (AA) pathway which converts AA into prostaglandin E(2). Amifostine was investigated for its renoprotective potential in RIR.

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