Amelioration of nephropathy with apoA-1 mimetic peptide in apoE-deficient mice | Zendy

Nosratola D. Vaziri | Zendy; Hwajin Kim | Zendy; Hamid Moradi | Zendy; Farbod Farmand | Zendy; Kaveh Navab | Zendy; Mohamad Navab | Zendy; Susan Hama | Zendy; Alan M. Fogelman | Zendy; Yasmir Quiroz | Zendy; Bernardo RodríguezIturbe | Zendy

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Amelioration of nephropathy with apoA-1 mimetic peptide in apoE-deficient mice

Author(s) -

Nosratola D. Vaziri,

Hwajin Kim,

Hamid Moradi,

Farbod Farmand,

Kaveh Navab,

Mohamad Navab,

Susan Hama,

Alan M. Fogelman,

Yasmir Quiroz,

Bernardo RodríguezIturbe

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq274

Subject(s) - oxidative stress , medicine , inflammation , apolipoprotein e , endocrinology , kidney disease , kidney , glomerulosclerosis , nephropathy , pathogenesis , proteinuria , immunology , diabetes mellitus , disease

There is mounting evidence that dyslipidaemia may contribute to development and progression of renal disease. For instance, hyperlipidaemia in apolipoprotein E-deficient (apoE(-/-)) mice is associated with glomerular inflammation, mesangial expansion and foam cell formation. ApoA-1 mimetic peptides are potent antioxidant and anti-inflammatory compounds which are highly effective in ameliorating atherosclerosis and inflammation in experimental animals. Given the central role of oxidative stress and inflammation in progression of renal disease, we hypothesized that apoA-1 mimetic peptide, D-4F, may attenuate renal lesions in apoE(-/-) mice.

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